Formyl-methionyl chemotatic peptide antibiotic conjugates...

Details Formyl-methionyl chemotatic peptide antibiotic conjugates... Formyl-methionyl chemotatic peptide antibiotic conjugates...

C - Chemistry, Metallurgy

07

K

530/5.04, 167/10

C07K 5/04 (2006.01) A61K 38/04 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1257747

ABSTRACT OF THE DISCLOSURE A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptide-antibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes and monocytes while simultaneously inhibiting the growth of microorganisms. The use of chemotactic peptide-silver sulfadiazine conjugates is particularly effective for treating burns.

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