Fosfluconazole derivatives, synthesis, and use in long...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/6518 (2006.01) A61K 31/675 (2006.01) A61P 17/00 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2754168

The invention relates to a compound of formula (I) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R1 to R8 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.

La présente invention concerne un composé de formule (I) et les sels, N-oxydes, amines quaternaires, et stéréoisomères de celui-ci, où R1 à R8 sont tels que définis dans les revendications. L'invention concerne en outre des intermédiaires et des procédés pour la préparation des composés de formule (I). L'invention concerne en outre les composés de formule (I) pour utilisation en tant que médicament, en particulier pour la prévention ou le traitement d'infections fongiques.

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