A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C08G 65/333 (2006.01)
Patent
CA 2631335
The invention relates to a dendrimer-like polymer structure having four monomethoxypolyethylenglycol branches, which can be represented as (I). The carboxylic group of the aforementioned structure can be functionalised in order to obtain conjugates of pharmaceutical interest. The binding of said dendrimer-like polyethylenglycol to therapeutic proteins improves the in vitro andin vivo stability of the latter.
L'invention concerne une structure polymère semblable à un dendrimère à quatre branches de monométoxypolyétylèneglycol susceptible d'être représentée comme suit: le groupe carboxylique de la structure antérieure peut être fonctionnalisé pour l'obtention de conjugués à intérêt pharmaceutique. L'union de ce polyéthylèneglycol semblable à des dendrimères avec des protéines thérapeutiques améliore la stabilité in vitro et in vivo de celles-ci.
Castro Odio Fidel Raul
Fernandez Sanchez Eduardo
Paez Meireles Rolando
Ramon Hernandez Jose Angel
Saez Martinez Vivian Maria
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
LandOfFree
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