Four-helical bundle protein zsig81

Details Four-helical bundle protein zsig81 Four-helical bundle protein zsig81

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C12N 5/0789 (2010.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2414214

This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.

La présente invention concerne des molécules de polypeptides et de polynucléotides codant pour une cytokine en faisceau à quatre hélices. Appelée zsig81, cette cytokine a une expression restreinte essentiellement au niveau du coeur, des poumons et du foie. Il est apparu que la cytokine zsig81 stimulait la prolifération de cellules hématopoïétiques, dont elle constitue des expansions utiles, et l'apparition d'états en rapport avec des cellules hématopoïétiques. Cette invention concerne des anticorps ainsi que des méthodes d'obtention de polypeptides zsig81.

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