Fowl cholera vaccine

Details Fowl cholera vaccine Fowl cholera vaccine

A - Human Necessities

61

K

167/135

A61K 39/002 (2006.01) A61K 39/102 (2006.01)

Patent

CA 1117416

Abstract of the Disclosure: The present invention relates to a live vaccine against Pasteurella multocida, for application of poultry by injection, per os or as aerosol, containing an attenuated non-virulent genetically stable strain of Pasteurella multocida, to a process for producing an attenuated genetically stable non-virulent strain of Pasteurella multocida, which comprises cultivating a virulent field strain, selecting after 18 hours at 37°C colonies of uniform size, of about 4 to 5 mm diameter, suspending these in a pH 5.5 buffer, subjecting same to a mutagen at a concentration causing a mortality of 90-99 % after 30 minutes at 37°C, centrifuging the microorganisms, washing sane, plating same and selecting colonies of not more than 2.5 to 3 mm diameter after 18 hours at 37°C, purifying by reisolation of single colonies, testing for antigenic specificity and virulence, and selecting avirulent genetically stable immunologically effective mutants fur use in vaccines, and to a process for the vaccination of poultry which comprises applying such a vaccine by injection, per os or as aerosol.

309863

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