Fractionation of polyalkylene oxide-conjugated hemoglobin...

Details Fractionation of polyalkylene oxide-conjugated hemoglobin... Fractionation of polyalkylene oxide-conjugated hemoglobin...

C - Chemistry, Metallurgy

07

K

C07K 1/18 (2006.01) A61K 35/14 (2006.01) A61K 38/42 (2006.01) A61K 47/48 (2006.01) C07K 14/805 (2006.01) C07K 17/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146869

Hemoglobin-containing solutions containing polyalkylene oxide-conjugated hemoglobin having a molecular weight grea- ter than about 85,000 daltons and a degree of substitution of at least five polyalkylene oxide conjugates per hemoglobin molecule are described that are not associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is also disclosed.

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