Fractionation of protein mixtures

Details Fractionation of protein mixtures Fractionation of protein mixtures

B - Operations, Transporting

01

D

204/98.04

B01D 57/02 (2006.01) A23J 1/00 (2006.01) A23J 1/06 (2006.01) C07K 1/36 (2006.01) C07K 14/745 (2006.01) C07K 14/765 (2006.01) C07K 16/06 (2006.01) G01N 27/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1151591

FRACTIONATION OF PROTEIN MIXTURES ABSTRACT This invention relates to the separation of complex protein mixtures by lowering (desalting) or by raising (salting-out) their electrolytic (ionic) concentration by electrodialysis followed by chilling, pH adjustment, filtration, and/or centrifugation and optionally thereafter restoration of the loss electrolyte or removal of the gained electrolyte and water. This technique is especially adaptable for therapeutic plasma exchange performed in situ for immunepheresis i.e. removal of globulin or immunecomplexes implicated in autoimmune diseases. The techniques are also applicable for antihemophilic factor separation and purification, and separation of proteins from whey.

371781

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