Fractionation of protein mixtures by salting out followed by...

C - Chemistry – Metallurgy – 07 – K

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167/139, 530/3.1

C07K 1/36 (2006.01) C07K 14/765 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1142175

FRACTIONATION OF PROTEIN MIXTURES BY SALT ADDITION FOLLOWED BY DIALYSIS TREATMENT ABSTRACT A process is descirbed for the fractionation of solutions of protein mixtures which includes the steps of subjecting such solutions to "salting-out", separation of the resulting turbidity, subsequent removal of the "salting-out" agent from the supernatant by dialysis and finally making up the original salt level of the liquid if required. Such a process may be used in therapeutic plasma exchange where removal of immunoglobulins or their complexes therefrom is desired so that the remaining albumin void of immunoglobulins can be administered back to the patient.

371840

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