Fragments and antagonists of heat shock protein 60

Details Fragments and antagonists of heat shock protein 60 Fragments and antagonists of heat shock protein 60

A - Human Necessities

61

K

A61K 39/00 (2006.01) A01N 63/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2394504

The invention identifies fragments of hsp60 which retain the capability of inducing a pro-inflammatory immune response of cells of the innate immune system. It is further disclosed the unexpectedfinding that smaller peptides derived from these fragments of hsp60 are capable of acting as antagonists of hsp60 insofar as they have the ability to reduce or even prevent the induction of a pro-inflammatory immune response by hsp60 in cells of the innate immune system. It further discloses variants, derivatives and analogs of such peptides, which are capable of acting as antagonists of hsp60 insofar as they have the ability to reduce or prevent the induction of a pro-inflammatory immune response by hsp60 in cells of the immune system. The invention also discloses pharmaceutical compositions comprising such peptide fragments or variants, derivatives and analogs thereof, and their use to prevent or ameliorate inflammatory diseases or disorders.

L'invention concerne les fragments de protéines de choc thermique 60, hsp60, qui conservent la capacité d'induire une réponse immune pro-inflammatoire des cellules du système immunitaire naturel. Elle concerne également le fait inattendu que de petits peptides dérivés de ces fragments de hsp60 peuvent agir comme antagonistes de hsp60, dans la mesure où ils peuvent réduire, voire empêcher l'induction d'une réponse immune pro-inflammatoire par hsp60 dans des cellules du système immunitaire naturel. Elle concerne aussi des variants, des dérivés et des analogues de tels peptides, qui sont capables d'agir comme antagonistes de hsp60 dans la mesure où ils peuvent réduire ou empêcher l'induction d'une réponse immune pro-inflammatoire par hsp60 dans des cellules du système immunitaire. L'invention concerne enfin des compositions pharmaceutiques contenant ces fragments de peptides ou leurs variants, dérivés et analogues, ainsi que leur utilisation pour empêcher ou traiter des maladies ou troubles inflammatoires.

Affiliated with

Also associated with

Rating

Fragments and antagonists of heat shock protein 60 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fragments and antagonists of heat shock protein 60, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fragments and antagonists of heat shock protein 60 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1894169