C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2091769
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species. An antibody which is capable of binding to human CD4 antigen is also provided together with a pharmaceutical composition comprising the antib- ody.
Clark Michael Ronald
Cobbold Stephen Paul
Gorman Scott David
Waldmann Herman
Clark Michael Ronald
Cobbold Stephen Paul
Gorman Scott David
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Wellcome Foundation Limited
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