C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C40B 40/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2602035
The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The invention also provides method of producing improved humanized antibodies. The present invention also provides antibodies produced by the methods of the invention.
L'invention porte sur des procédés de re-ingénierie et de re-façonnage d'anticorps afin de réduire l'immunogénicité des anticorps, tout en conservant l'immunospécificité des anticorps pour un antigène. Plus précisément, cette invention porte sur des procédés de fabrication d'anticorps immunospécifiques à un antigène par synthèse d'une bibliothèque combinatoire comprenant des zones de détermination de complémentarité (CDR) d'un anticorps de donneur fusionné en ossature, en zones d'infrastructure à partir d'une sous-banque de zones d'infrastructure. Cette invention porte aussi sur un procédé de fabrication d'anticorps humanisés améliorés. Elle concerne également des anticorps fabriqués au moyen des procédés de l'invention.
Dall'acqua William
Damschroder Melissa
Wu Herren
Medimmune Inc.
Smart & Biggar
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