Free ngal as a biomarker for cancer

Details Free ngal as a biomarker for cancer Free ngal as a biomarker for cancer

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2642833

Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH)3 a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed to measuring uncomplexed NGAL levels in urine as a primary screen to determine if an individual is either at risk of developing, or has developed cancer, e.g., cancer of epithelial origin including breast and ovarian cancer.

La lipocaline neutrophile associée à la gélatinase (NGAL) non complexée est présente à des niveaux accrus chez les individus présentant une hyperplasie ductale atypique (ADH), un facteur de risque majeur pour le développement ultérieur du cancer du sein ; chez les individus atteint de cancer de l'ovaire ; et chez les individus atteints de cancer du sein, tant invasif que non invasif. En conséquence, la présente invention concerne la mesure des taux de NGAL non complexée dans l'urine à titre de dépistage primaire pour déterminer si un individu est à risque de développer ou bien a développé un cancer, par exemple un cancer d'origine épithéliale, comprenant le cancer du sein et le cancer de l'ovaire.

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