Freeze-dried composition of bone morphogenetic protein human...

Details Freeze-dried composition of bone morphogenetic protein human... Freeze-dried composition of bone morphogenetic protein human...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 9/19 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2278546

A stable freeze-dried composition of a bone morphogenetic protein human MP52 wherein coloration and shrinking of MP52 during storage and aggregation at the re-dissolution can be prevented. The composition is obtained by mixing MP52 with mannitol at a weight ratio of 1 : 5 to 1 : 50 followed by freeze-drying.

Cette invention se rapporte à une composition lyophilisée stable de MP52 humaine de protéines morphogénétiques osseuses, dans laquelle la coloration et le rétrécissement de la MP52 pendant son entreposage et son agglomération au moment de la redissolution peuvent être empêchés. On obtient cette composition en mélangeant la MP52 avec du mannitol selon un rapport en poids compris entre 1/5 et 1/50 puis en la soumettant à une lyophilisation.

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