A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/44 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) C07K 14/75 (2006.01) C12N 5/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2514474
The present invention relates to porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents, and methods of producing said matrices. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three dimensional cell growth are obtained from plasma proteins substantially devoid of plasminogen or from partially purified plasma proteins, thus obviating the need for exogenous anti- fibrinolytic agents. Furthermore, incorporation of glycosaminoglycans and bioactive agents during the formation of the matrix results in a sponge having advantageous biological, mechanical and physical properties. The compositions of the present invention are useful clinically, per se or as cell-bearing implants.
L'invention concerne des matrices de fibrine poreuses lyophilisées sensiblement dépourvues d'agents anti-fibrinolytiques externes, et des procédés de production desdites matrices. On obtient des matrices résiliantes, connues également comme éponge, particulièrement avantageuses pour supporter une croissance cellulaire tridimensionnelle à partir de protéines du plasma sensiblement dépourvues de plasminogène ou de protéines du plasma partiellement purifiées, ce qui évite d'avoir recours à des agents anti-fibrinolytiques exogènes. En outre, l'incorporation de glycosaminoglycanes et d'agents bioactifs pendant la formation de la matrice produit une éponge possédant des propriétés biologiques, mécaniques et physiques avantageuses. Les compositions de l'invention sont cliniquement utilisées per se ou comme implants portant des cellules.
Azachi Malkit
Gladnikoff Micha
Yayon Avner
Prochon Biotech Ltd.
Ridout & Maybee Llp
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