A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01)
Patent
CA 2205600
The invention relates to a freeze-dried dosage form for oral administration capable of being rapidly disintegrated in the mouth comprising ondansetron in the form of its free base or a pharmaceutically acceptable solvate thereof and one or more pharmaceutically acceptable excipients. Methods for the manufacture of such compositions and for their use in the treatment of conditions mediated through the action of 5-hydroxytryptamine (5HT) at 5HT3 receptors are also described.
L'invention concerne une forme galénique lyophilisée, destinée à une administration orale, susceptible de se désintégrer rapidement dans la bouche, et comprenant de l'ondansétron sous la forme de sa base libre ou d'un solvate de celle-ci, acceptable sur le plan pharmacologique, ainsi qu'un ou plusieurs excipients acceptables sur le plan pharmacologique. On décrit également des procédés de fabrication de telles compositions ainsi que l'utilisation de celles-ci dans le traitement d'états induits par l'action de 5-hydroxytryptamine (5HT) au niveau des récepteurs 5HT¿3?.
Glaxo Wellcome Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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