Freeze-dried pharmaceutical compositions of phenylquinoline...

Details Freeze-dried pharmaceutical compositions of phenylquinoline... Freeze-dried pharmaceutical compositions of phenylquinoline...

A - Human Necessities

61

K

167/159, 167/163

A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 31/47 (2006.01) A61K 47/28 (2006.01)

Patent

CA 1312824

Title BP-6300-A Freeze-Dried Pharmaceutical Compositions of Phenylquinoline Carboxylic Acids Abstract of the Disclosure Freeze-dried pharmaceutical compositions of antitumor phenylquinoline carboxylic acids, such as 6-fluoro-2-(2'-fluoro-1'-biphenyl-4-yl) 3-methyl-4- quinolinecarboxylic acid, sodium salt, reconstitutable to stable, aqueous, injectable compositions are pro- vided. These compositions use a stabilization system consisting essentially of a bile salt, such as sodium cholate or sodium desoxycholate, and a base or buffer that will provide a pH of about 8.5-11 upon aqueous reconstitution. Glycine is the preferred buffer.

544796

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