Freeze-drying process for the preparation of meningococcus...

Details Freeze-drying process for the preparation of meningococcus... Freeze-drying process for the preparation of meningococcus...

A - Human Necessities

61

K

167/135

A61K 39/02 (2006.01) A61K 39/095 (2006.01)

Patent

CA 1112168

TITLE OF THE INVENTION: Freeze-Drying Process for the Pre- paration of Meningococcus Vaccine Without Degradation of Potency. ABSTRACT OF THE DISCLOSURE: The purified Group A polysaccharide antigen isolated fron N. meningitidis for vaccination against this type of bacterial meningi- tidis is prepared from an isotonic ratio of aqueous sodium chloride solution freeze-dried at temperatures of from -20°C. to -30°C. This low temperature lyophilization dries the sodium chloride polysaccharide menstrum without loss of molecular weight, i.e., potency.

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