Frizzled proteins and detection and treatment of cancer

G - Physics – 01 – N

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G01N 33/53 (2006.01) A61K 38/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2580780

The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.

L'invention concerne notamment des procédés d'utilisation de gènes, de protéines Wnt et FZD et de sondes et d'anticorps spécifiques de FZD et Wnt dans le diagnostic et le traitement du cancer, ainsi que dans le criblage de composés d'essai dans le domaine de la cancérothérapie. Par ailleurs, l'invention concerne des composés utilisés pour traiter le cancer, tel que le cancer du foie.

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