Fsh producing cell clone

Details Fsh producing cell clone Fsh producing cell clone

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/59 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2690844

The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the .alpha.- and the .beta.-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The present invention further relates to a recombinant nucleic acid molecule comprising such nucleic acid sequences and host cells containing such recombinant nucleic acid molecules, as well as their use in the production of recombinant human FSH. Finally, the present invention also relates to a method for producing host cells expressing human follicle stimulating hormone by transfecting cells in suspension culture under serum- free conditions with the recombinant nucleic acid molecule of the present invention.

La présente invention concerne des molécules d'acides nucléiques comportant une séquence d'acides nucléiques codant pour la chaîne alpha et la chaîne bêta de l'hormone de stimulation folliculaire (FSH) humaine, respectivement, qui a été modifiée par rapport à l'utilisation des codons dans des cellules CHO. La présente invention concerne également une molécules d'acides nucléiques recombinante comportant de telles séquences d'acides nucléiques et des cellules hôtes contenant de telles molécules d'acides nucléiques recombinantes, ainsi que leur utilisation dans la production de FSH humaine recombinante. Enfin, la présente invention concerne également un procédé de production de cellules hôtes exprimant l'hormone de stimulation folliculaire humaine par la transfection de cellules dans une culture en suspension dans des conditions exemptes de sérum avec la molécule d'acides nucléiques selon la présente invention.

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