Fsh-releasing peptide

Details Fsh-releasing peptide Fsh-releasing peptide

C - Chemistry, Metallurgy

07

K

530/7.2

C07K 7/20 (1990.01) A61K 37/43 (1990.01)

Patent

CA 1302651

FSH-RELEASING PEPTIDE ABSTRACT OF THE DISCLOSURE A 28,000-dalton protein with FSH-releasing activity is isolated from porcine follicular fluid in a multi-step procedure including gel filtration, ion exchange chromatography and several reverse-phase high-performance liquid chromatography steps. The 28 kD protein promotes secretion of FSH, but not of LH, in a rat anterior pituitary monolayer culture system, exhibiting an EC50 of 0-5 ng/ml.

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