Fto gene polymorphisms associated to obesity and/or type ii...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2682839

The present invention provides means and methods for risk assessment and/or diagnosis and/or prognosis of obesity and/or type Il diabetes in humans, based on the detection of nucleic acid biomarkers belonging to, or associated with, a set of SNPs in the fatso (FTO) gene. The present invention also provides means and methods for identifying a SNP haplotype associated with obesity and/or type Il diabetes susceptibility in humans, for selecting pharmaceutical agents useful in prevention and/or treatment of obesity and/or type Il diabetes in humans, for haplotyping the fatso (FTO) gene in humans.

La présente invention concerne des moyens et des procédés pour l'évaluation du risque et/ou le diagnostic et/ou le pronostic de l'obésité ou du diabète de type II chez les êtres humains, sur la base de la détection de biomarqueurs d'acide nucléique appartenant à, ou associés avec, un ensemble de SNP dans le gène fatso (FTO). La présente invention concerne également des moyens et des procédés pour identifier un haplotype de SNP associé à la sensibilité à l'obésité et/ou au diabète de type II chez les êtres humains, pour sélectionner des agents pharmaceutiques utiles dans la prévention et/ou le traitement de l'obésité et/ou du diabète de type II chez les êtres humains, pour l'haplotypage du gène fatso (FTO) chez les êtres humains.

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