Fucopeptides

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C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 38/14 (2006.01) C07H 7/02 (2006.01) C07H 15/04 (2006.01) C07H 15/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2214107

Compounds of formula (I) wherein R is CH3 and R1 is a peptidic residue or R1 is OH and R is a peptidic residue have pharmacological activity as sialyl Lewis X mimetics, e.g. in the prevention or treatment of disorders or diseases which are mediated by the binding of selectins in cellular adhesion.

Les composés de la formule (I), dans laquelle R représente CH¿3? et R¿1? est un résidu peptidique où R¿1? représente OH et R est un résidu peptidique, possèdent un effet pharmacologique en tant que mimétiques de Lewis X syaliles, par exemple dans la prévention ou le traitement de troubles ou maladies qui sont induits par la liaison des sélectines dans l'adhérence cellulaire.

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