Full-length infectious cdna clones of tick borne flavivirus

Details Full-length infectious cdna clones of tick borne flavivirus Full-length infectious cdna clones of tick borne flavivirus

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2400182

Provided are full-length cDNA clones of Langat tick-borne flavivirus. In particular, the strains TP21 and E5 were obtained as full-length clones in single plasmids. Production of virions from cloned full length cDNA resulted in variants wih reduced neurovirulence. Deletions in the 3' NCR also decreased neurovirulence. The attenuated variants of Langat tick-borne flavivirus may be used for vaccination purposes.

La présente invention concerne un clone d'ADNc infectieux de pleine longueur de flavivirus à tiques Langat.

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