C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/23 (2006.01) A61K 38/21 (2006.01) C07K 14/47 (2006.01) C07K 14/57 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2491178
The present invention relates to novel full-length interferon gamma (IFNG) polypeptide variants having interferon gamma activity. The full-length interferon gamma polypeptide variants of the invention are obtained by performing selected modifications in the C-terminal part of the molecule. The variant comprises at least one amino acid substitution in one of the positions S132 and S142, and at least one amino acid substitution in one of the positions R137, R139 and R140. Alternatively, the variant comprises at least amino acid substitutions in positions R137 and R140. The full-length interferon gamma polypeptide variants of the invention are useful in therapy, in particular for the treatment of interstitial pulmonary diseases, such as idiopathic pulmonary fibrosis.
La présente invention concerne de nouveaux variants polypeptidiques à interféron gamma pleine longueur (IFNG) ayant une activité d'interféron gamma. Les variants polypeptidiques à interféron gamma pleine longueur sont obtenus par des modifications sélectionnées dans la partie terminale C de la molécule. Les variants polypeptidiques à interféron gamma pleine longueur selon l'invention sont utiles dans le traitement de maladies, notamment dans le traitement de maladies pulmonaires interstitielles, telles qu'une fibrose pulmonaire idiopathique.
Andersen Kim Vilbour
Jensen Anne Dam
Nygaard Frank Bech
Van Den Hazel Bart
Andersen Kim Vilbour
Fetherstonhaugh & Co.
Jensen Anne Dam
Maxygen Holdings Ltd.
Nygaard Frank Bech
LandOfFree
Full-length interferon gamma polypeptide variants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Full-length interferon gamma polypeptide variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Full-length interferon gamma polypeptide variants will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1960561