Fully human anti-vegf antibodies and methods of using

Details Fully human anti-vegf antibodies and methods of using Fully human anti-vegf antibodies and methods of using

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2702637

Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.

Cette invention concerne des anticorps entièrement humains et d'autres fragments se liant à l'antigène, qui se lient spécifiquement au VEGF humain et inhibent la liaison du VEGF aux récepteurs VEGF-R1 et VEGF-R2, inhibant ainsi la signalisation VEGF. Les anticorps et fragments se liant à l'antigène de l'invention peuvent être utilisés, par exemple, pour traiter l'angiogenèse et les affections associées à l'angiogenèse à la fois in vivo et in vitro.

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