Fully human anti-vegf antibodies and methods of using

Details Fully human anti-vegf antibodies and methods of using Fully human anti-vegf antibodies and methods of using

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2666974

Vascular endothelial growth factor (VEGF) overexpression is associated with a variety of conditions involving aberrant angiogenesis. Disclosed herein are fully human antibodies that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. Based on their ability to inhibit VEGF signaling, the antibodies disclosed herein may be used to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.

Cette invention se rapporte à la surexpression du facteur de croissance de l'endothélium vasculaire (VEGF), cette surexpression étant associée avec différentes affections impliquant une angiogenèse aberrante. L'invention concerne des anticorps entièrement humains qui se fixent spécifiquement au facteur VEGF humain et inhibent la fixation du facteur VEGF aux récepteurs VEGF-R1 et VEGF-R2, inhibant ainsi la signalisation du VEGF. Basés sur leur capacité à inhiber les voies de signalisation du facteur VEGF, les anticorps décrits dans l'invention peuvent être utilisés pour traiter l'angiogenèse et les affections associées avec l'angiogenèse à la fois in vivo et in vitro.

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