Fully human antibodies against human 4-1bb (cd137)

C - Chemistry – Metallurgy – 07 – K

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C07K 16/28 (2006.01)

Patent

CA 2542044

Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.

L'invention concerne des anticorps entièrement humains ainsi que des fragments de liaison à l'antigène qui se lient à la 4-1BB humaine et qui favorisent la liaison de la 4-1BB humaine à un ligand de la 4-1BB humaine. Dans un premier aspect, l'anticorps et un anticorps IgG4. Par ailleurs, l'invention concerne une méthode de traitement d'une maladie chez un sujet, qui consiste à lui administrer une dose thérapeutiquement efficace de l'anticorps.

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