Fully human antibodies directed against the human...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2524305

This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodes, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with anti-neoplastic drugs.

L'invention concerne des anticorps humains se liant au récepteur du facteur de croissance de type 1 (IGF-IR), des dérivés de ces anticorps (Fab, anticorps à une seule chaîne, anticorps bi-spécifiques ou protéines hybrides), et des utilisations des anticorps et de leurs dérivés dans des procédés thérapeutiques et diagnostiques. L'invention concerne également des acides nucléiques codant le récepteur du facteur de croissance de type 1, des procédés de fabrication des anticorps et l'expression de ceux-ci. L'invention concerne par ailleurs des thérapies de combinaison faisant intervenir des anticorps anti-IGF-IR et des médicaments anti-néoplasiques.

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