Fully human antibodies specific to cadm1

Details Fully human antibodies specific to cadm1 Fully human antibodies specific to cadm1

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2753702

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immuno-conjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

La présente invention concerne des anticorps monoclonaux isolés, notamment des anticorps monoclonaux humains, plus particulièrement des anticorps obtenus par génie génétique, qui résultent en une augmentation de la liaison aux récepteurs Fc et/ou une augmentation de la puissance pour ADCC ou des immunoconjugués, qui se lient spécifiquement à CADM1 avec une grande affinité. L'invention concerne également des molécules d'acides nucléiques codant pour des anticorps CADM1, des vecteurs d'expression, des cellules hôtes et des procédés d'expression des anticorps CADM1. L'invention concerne également des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps CADM1. L'invention concerne également des procédés de détection de CADM1, ainsi que des procédés de traitement de divers cancers, y compris le cancer du poumon et le cancer du pancréas.

Affiliated with

Also associated with

Rating

Fully human antibodies specific to cadm1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fully human antibodies specific to cadm1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fully human antibodies specific to cadm1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2051347