C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2737597
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect HMW-MAA in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.
L'invention porte sur des anticorps monoclonaux humains isolés et sur des fragments fonctionnels de ceux-ci, qui se lient spécifiquement à MAA de masse moléculaire élevée (HMW-MAA). L'invention porte également sur des acides nucléiques codant pour ces anticorps, sur des vecteurs d'expression comprenant ces molécules d'acide nucléique et sur des cellules hôtes isolées qui expriment les molécules d'acide nucléique. Les anticorps peuvent être utilisés pour détecter HMW-MAA dans un échantillon. L'invention porte également sur des procédés de diagnostic d'un cancer, ou de confirmation d'un diagnostic de cancer, qui utilisent ces anticorps. L'invention porte également sur des procédés de traitement d'un sujet ayant un cancer.
Ferrone Soldano
Wang Xinhui
Smart & Biggar
University Of Pittsburgh-Of The Commonwealth System Of Higher Ed
LandOfFree
Fully human antibodies to high molecular weight-melanoma... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fully human antibodies to high molecular weight-melanoma..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fully human antibodies to high molecular weight-melanoma... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1858805