C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07K 14/57 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2502668
Selective binding agents of interferon-gamma (IFN.UPSILON.) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to IFN.UPSILON. and may be used to prevent or treat conditions relating to autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. Nucleic acid molecules encoding said antibodies and antigen binding domains, and expression vectors and host cells for the production of same are also provided.
L'invention concerne des agents de liaison sélectifs de l'interféron-gamma (IFN.UPSILON.). L'invention concerne plus particulièrement des antigènes et des domaines de liaison d'antigènes se liant sélectivement à IFN.UPSILON. et pouvant être utilisés dans la prévention ou le traitement de troubles associés à des maladies auto-immunes ou inflammatoires telles que l'arthrite rhumatoïde, le lupus érythémateux systémique et la sclérose en plaques. L'invention concerne également des molécules d'acides nucléiques codant de tels anticorps et domaines de liaison d'antigènes, ainsi que des vecteurs d'expression et des cellules hôtes destinés à la production desdites molécules.
Deshpande Rajendra V.
Tsai Mei-Mei
Amgen Inc.
Smart & Biggar
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