Fumaric acid derivatives, process for the production thereof...

Details Fumaric acid derivatives, process for the production thereof... Fumaric acid derivatives, process for the production thereof...

C - Chemistry, Metallurgy

07

C

167/179, 260/481

C07C 69/60 (2006.01) A01N 37/02 (2006.01) A61K 31/07 (2006.01) A61K 31/22 (2006.01) A61K 31/225 (2006.01) A61K 31/35 (2006.01) A61K 31/57 (2006.01) A61K 31/59 (2006.01) A61K 31/685 (2006.01) A61K 31/70 (2006.01) C07C 55/00 (2006.01) C07C 67/14 (2006.01) C07C 401/00 (2006.01) C07C 403/08 (2006.01) C07D 311/72 (2006.01) C07D 493/04 (2006.01) C07F 9/10 (2006.01) C07H 13/04 (2006.01) C07J 5/00 (2006.01)

Patent

CA 1310959

FUMARIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Abstract Of The Invention Fumaric acid derivatives of the formula Image (I) wherein R1 is a hydrogen atom, a C1-C8 alkyl group or a metallic cation, and R2 is a saturated or unsaturated aliphatic C6-C24 alkyl group, psoralen-9-yl, retinyl, .alpha.-tocopheryl (vitamin E), calciferyl, corticoateroid-21-yl or monosaccharid- .omega.-yl; a group of fumaric acid derivatives based on glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the formula (IX) Image wherein n is an integar from to 30 to 260, R3 is a hydrogen atom or a C1-C3 alkyl group, R4 is one of the R3 groups and n iq the number of molecule repetitions, processes for their productlon and composltions contalnlng same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial actior.

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