C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/17 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2090407
2090407 9205447 PCTABS00011 Hormone receptors and the transcription factor Jun/AP-1 have been shown to reciprocally repress one another by a mechanism which is independent of DNA binding. For example, over-expression of AP-1 represses glucocorticoid-induced activation of genes carrying a functional glucocorticoid response element. Conversely, glucocorticoid has been shown to repress the transcriptional activation of genes which are controlled by promoters which contain the AP-1 binding site. In addition, methods are disclosed for selecting compounds useful for treating cells undergoing uncontrolled proliferation, such compounds being capable of disrupting the function of AP-1, but display substantially no ability to promote the transcriptional activation of hormone responsive genes.
Evans Ronald M.
Schule Roland
Gowling Lafleur Henderson Llp
Salk Institute For Biological Studies
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