Functional cardiomyocytes from human embryonic stem cells

Details Functional cardiomyocytes from human embryonic stem cells Functional cardiomyocytes from human embryonic stem cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2493588

Human embryonic stem cells form embryoid bodies in culture which contain differentiated human cells. Some of the human cells in embryoid bodies differentiate into cardiomyocytes. Here the biological and electrical characteristics of those cardiomyocytes are described with reference to the use of cardiomyocytes derived from human embryonic stem cells in drug screening protocols for mechanisms of cardiac toxicity.

Des cellules souches embryonnaires humaines forment des corps embryoïdes dans une culture, qui contiennent des cellules humaines différenciées. Quelques unes de ces cellules humaines des corps embryoïdes se différencient en cardiomyocyte. L'invention concerne les caractéristiques biologiques et électriques de ces cardiomyocytes par rapport à l'utilisation de cardiomyocytes provenant de cellules souches embryonnaires humaines dans des protocoles de criblage de médicaments afin de rechercher des mécanismes de toxicité cardiaque.

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