C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2464372
The present invention relates to functional heavy chain antibodies, functional single domain heavy chain antibodies, functional VH domains, or functional fragments thereof comprising an amino acid which is neither a charged amino acid nor a C at position 45, and comprising an amino acid at position 103 independently chosen from the group consisting of R, G, K, S, Q, L, and P, and optionally an amino acid at position 108 independently chosen from the group consisting of Q, L and R, said positions determined according to the Kabat numbering.
La présente invention concerne des anticorps fonctionnels à chaîne lourde, des anticorps fonctionnels à chaîne lourde à domaine unique, des domaines fonctionnels VH, ou des fragments fonctionnels de ces derniers comprenant un acide aminé qui n'est pas un acide aminé chargé ni un C en position 45, et comprenant un acide aminé en position 103 choisi indépendamment dans le groupe composé de R, G, K, S, Q, L, et P, et facultativement un acide aminé en position 108 choisi indépendamment dans le groupe composé de Q, L et R, les positions précitées étant choisies selon la numérotation de Kabat.
Muyldermans Serge
Nguyen Viet Khong
Borden Ladner Gervais Llp
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw
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