Functional method for generating or screening for ligands...

Details Functional method for generating or screening for ligands... Functional method for generating or screening for ligands...

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) C07K 14/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2558664

This application presents the discovery that the Vitamin D3 receptor (VDR), a member of the nuclear hormone ligand-activated receptor superfamily, interacts with a MNAR, a scaffolding protein. This interaction results in the formation of a ternary complex between VDR, MNAR, and the Src or PI3 kinase families of tyrosine kinases to mediate cell signaling, especially in osteoblast cells.

La présente demande est fondée sur la découverte que le récepteur de la vitamine D3 (VDR), membre de la superfamille des récepteurs activés par les ligands d'hormones nucléaires, interagit avec une MNAR, à savoir une protéine de squelette. Cette interaction entraîne la formation d'un complexe ternaire à base de VDR, de MNAR et des familles kinases Src ou PI3 des tyrosine-kinases dans le but d'assurer une médiation de la signalisation cellulaire, notamment dans les cellules ostéoblastiques.

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