Functional mutations in respiratory syncytial virus

Details Functional mutations in respiratory syncytial virus Functional mutations in respiratory syncytial virus

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 6/00 (2006.01) A61K 35/76 (2006.01) A61K 39/155 (2006.01) A61P 31/14 (2006.01) C07K 14/135 (2006.01) C12N 7/01 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2499042

The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

La présente invention concerne des virus respiratoires syncytiaux de recombinaison, lesquels présentent un phénotype atténué et comprennent une ou plusieurs mutations des protéines P , M2-1 et/ou M2-2 virales, ainsi que des vaccins vivants atténués comprenant de tels virus et des acides nucléiques codant pour de tels virus. Cette invention concerne les protéines de recombinaison RSV P, M2-1 et M2-2. L'invention concerne également des méthodes permettant de produire des virus respiratoires syncytiaux de recombinaison atténués, ainsi que des procédés permettant de quantifier les anticorps neutralisants au moyen des virus de recombinaison de la famille Paramyxoviridae.

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