Functional protein expression for rapid cell-free phenotyping

Details Functional protein expression for rapid cell-free phenotyping Functional protein expression for rapid cell-free phenotyping

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2430201

Methods and compositions for detecting the phenotype of a bioactive molecule assays. More specifically, are provided methods and compositions are provided for determiningthe suitability of one ore more candidate compounds prior to or during the course of chemotherapy or anti-infective therapy, for their capacity to inhibit the bioactive molecules of micro-organisms, cancers and as an assay for expression in transgene therapy. Also provided are phenotypic assays for drug discovery.

L'invention concerne des méthodes et des compositions destinées à la détection du phénotype d'une molécule bioactive. L'invention concerne plus précisément des méthodes et des compositions permettant de déterminer, avant ou durant une chimiothérapie ou une thérapie anti-infectieuse, si un ou plusieurs composés d'intérêt inhibent les molécules bioactives de microorganismes, et de cancers. Ces compositions peuvent être utilisées comme dosage pour mesurer l'expression de gènes en thérapie transgénique. L'invention concerne également des analyses phénotypiques destinées à la découverte de nouveaux médicaments.

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