Functional toll-like receptors (tlr) on melanocytes and...

Details Functional toll-like receptors (tlr) on melanocytes and... Functional toll-like receptors (tlr) on melanocytes and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 45/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2685557

The invention relates to a method of detecting Toll-like receptor (TLR) gene expression or protein activity in a melanocyte or melanoma cell. Also disclosed are a method of modulating TLR gene expression or protein activity in a melanocyte or melanoma cell by contacting the cell with a TLR modulating agent and a method of inhibiting melanoma cell migration (e.g., spreading) by contacting the cell with a TLR inhibitor.

Cette invention se rapporte à un procédé de détection de l'expression du gène du récepteur TLR (Toll-like receptor) ou de son activité protéinique dans un mélanocyte ou une cellule de mélanome. L'invention se rapporte également à un procédé permettant de moduler l'expression du gène du TLR ou de son activité protéinique dans un mélanocyte ou une cellule de mélanome en mettant en contact la cellule avec un agent modulant le TLR; l'invention concerne par ailleurs un procédé permettant d'inhiber la migration de la cellule de mélanome (par exemple par propagation) par mise en contact de la cellule avec un inhibiteur de TLR.

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