Functionalised materials and uses thereof

Details Functionalised materials and uses thereof Functionalised materials and uses thereof

C - Chemistry, Metallurgy

07

F

C07F 7/21 (2006.01) A61K 9/14 (2006.01) C01B 33/14 (2006.01) C08G 77/28 (2006.01) C08G 77/50 (2006.01)

Patent

CA 2702988

[(03/2)Si CH2CH2SX] a[Si (04/2)] b[WSi (03/2)] c [VSi (03/2)] d wherein X is selected from (CR1R2 )eNR5 CO NHR, (CR1R2)eNR5 CS NHR, W when present is selected from (CR6 R2)e ZR, (CH2)3 SRl (CH2)3 NRR1, (CH2)e SR8, CH2CH2S (CR1R2 )fNR5 CO NHR, CH2CH2S (CR1R2 ),NR5 CS NHR, CH2CH2S (CH2)f OR; Z is 0 or S, R, R1-7 are independently selected from hydrogen, alkyl group, aryl group or alkylaryl group, R8 is selected from [CH2CH2NR1]p R2 and (CR1R2)m SR9 where R9 is hydrogen, Cl-22-alkyl group, and V is a group which is optionally substituted and selected from a C1-22-alkyl group, C2-22-alkenyl group, a C2-22-alkynyl group or an aryl group. The compounds are useful as immobilisation materials for bio-molecules including enzymes, cation and anion exchangers, organic and inorganic compound scavengers, solid phase purification or extraction materi-als, removal and purification of biological compounds including endotoxins, anti- microbial agents, hydrophilicity modifiers, flame proofing agents, antistatic agents, coatings for biomedical devices, water repellent films and coatings, solid phase synthesis materials and chromatography materials.

[(O3/2)Si CH2CH2SX] a [Si (O4/2)] b [WSi (O3/2)] c [VSi (O3/2)] d, X étant choisi parmi (CR1R2)eNR5 CO NHR, (CR1R2)eNR5 CS NHR ; W, lorsqu'il est présent, étant choisi parmi (CR6R7)e ZR, (CH2)3 SR1 (CH2)3 NRR1, (CH2)e SR8, CH2CH2S (CR1R2)fNR5 CO NHR, CH2CH2S (CR1R2), NR5 CS NHR, CH2CH2S (CH2)f OR ; Z représentant O ou S, R, les R1 à R7 étant indépendamment choisis parmi un hydrogène, un groupe alkyle, un groupe aryle ou un groupe alkylaryle, R8 étant choisi parmi [CH2CH2NR1]P R2 et (CR1R2)m SR9 où R9 représente un hydrogène, un groupe alkyle en C1 à C22, et V étant un groupe qui est éventuellement substitué et choisi parmi un groupe alkyle en C1 à C22, un groupe alcényle en C2 à C22, un groupe alcynyle en C2 à C22 ou un groupe aryle. Les composés sont utiles en tant que matériaux d'immobilisation pour des molécules biologiques y compris les enzymes, des échangeurs cationiques et anioniques, des agents désactiveurs de composés organiques et inorganiques, des matériaux de purification ou d'extraction en phase solide, des agents d'élimination et de purification de composés biologiques, notamment des endotoxines, des agents anti-microbiens, des modificateurs de l'hydrophilie, des agents ignifuges, des agents antistatiques, des revêtements pour dispositifs biomédicaux, des films et des revêtements hydrophobes, des matériaux de synthèse en phase solide et des matériaux de chromatographie.

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