Functionalised siloxanes for scar tissue treatment

Details Functionalised siloxanes for scar tissue treatment Functionalised siloxanes for scar tissue treatment

A - Human Necessities

61

K

A61K 31/80 (2006.01) A61L 27/60 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2565054

A novel composition for use in treating a wound, burn or other skin condition comprises one or more compounds of formula (I), wherein: m = 0-6, n = 6-100, Q, R and R' may be independently selected from, C1-5 alkyl, OU, UOCH2CH3, CH2CH3, UOCH3, OH, O(CH2)y(OU)yCH3, (OCH2CH2)yOU, (OCH2CH2)yOH, UOH, UOU', UCO2U', CO2U, UCO2COU', CO2H, UCO2H, COX, UCOX, UCO2 R', CO2COU, Aryl, ArylU, ArylUU', ArylUU'U'', NH2, UNH2, NHU, NUU', NO2, UNO2, UCONH2, CONH2, UCONHU', CONHU, UCONU'U'', CONU'U'', halogen, PO4H3, PO4H3-z, PO4H3-zU (z = 0, 1, 2 or 3), PU3, P U'U''U''' SH, SO2 and SO3H; wherein U, U', U'' and U''' may be independently selected from any alkyl, alkenyl or alkynyl group where the number of carbon atoms is between 1 and 31; wherein X = halogen; wherein y = 1-100; provided that Q, R and R' can not all be C1 alkyl; and wherein the compound of formula (I) is present in an amount of at least 1% of the composition.

Cette invention se rapporte à une nouvelle composition conçue pour être utilisée dans le traitement des plaies, des brûlures ou d'autres états de la peau, cette composition comprenant un ou plusieurs composés représentés par la formule (I), dans laquelle: m = 0-6, n = 6-100, Q, R et R' peuvent être choisis séparément parmi alkyle C¿1-5?, OU, UOCH¿2?CH¿3?, CH¿2?CH¿3?, UOCH¿3?, OH, O(CH¿2?)¿y?(OU)¿y?CH¿3?, (OCH¿2?CH¿2?)¿y?OU, (OCH¿2?CH¿2?)¿y?OH, UOH, UOU', UCO¿2?U', CO¿2?U, UCO¿2?COU', CO¿2?H, UCO¿2?H, COX, UCOX, UCO¿2? R', CO¿2?COU, Aryl, ArylU, ArylUU', ArylUU'U'', NH¿2?, UNH¿2?, NHU, NUU', NO¿2?, UNO¿2?, UCONH¿2?, CONH¿2?, UCONHU', CONHU, UCONU'U'', CONU'U'', halogène, PO¿4?H¿3?, PO¿4?H¿3-z?, PO¿4?H¿3-z?U (z = 0, 1, 2 ou 3), PU¿3?, P U'U''U''' SH, SO¿2? et SO¿3?H; où U, U', U''et U''' peuvent être choisis séparément parmi un groupe alkyle, alcényle ou alkynyle, dont le nombre d'atomes de carbone est compris entre 1 et 31; et où X = halogène; et y = 1-100; à condition que Q, R et R' ne puissent pas représenter tous alkyle C1; et où le composé de formule (I) est présent en une quantité d'au moins 1 % de la composition.

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