C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/29 (2006.01) C07K 14/18 (2006.01) C07K 17/02 (2006.01)
Patent
CA 2479021
The present invention relates to compositions comprising vesicles released' from activated T lymphocytes, as well as to methods for their production and uses. Said vesicles contain a set of bioactive molecules which confer remarkable properties, such as antigen recognition, antigen presentation and other regulatory and effector functions. This invention also relates to methods for transferring or delivering antigenic molecules (e.g., peptides, peptide/MHC complexes, TCR or subunit thereof, etc.) to antigen presenting cells (APCs) using said vesicles, to induce specific immune responses, particularly specific CTL responses. The invention further relates to methods of delivering molecules selectively or specifically to target cells using said vesicles.
L'invention concerne des compositions contenant des vésicules libérées par les lymphocytes T activés, et des procédés de production et d'utilisation de celles-ci. Ces vésicules contiennent un ensemble de molécules bioactives qui leur confèrent des propriétés remarquables telles que reconnaissance d'antigène, présentation d'antigène et d'autres fonctions régulatrices et effectrices. L'invention concerne aussi des procédés permettant de transférer ou d'apporter des molécules antigéniques (p. ex. peptides, complexes peptide/CMH, TCR ou sous-unité de celui-ci, etc.) à des cellules présentatrices d'antigène (APC) au moyen desdites vésicules, afin d'induire des réactions immunitaires spécifiques, en particulier des réactions de cellules T cytotoxiques spécifiques. L'invention concerne de plus des procédés d'apport sélectif ou spécifique de molécules à des cellules cibles au moyen de ces vésicules.
Hou Yafei
Hsu Di-Hwei
Lamparski Henry
Le Pecq Jean-Bernard
Mehta-Damani Anita
Anosys Inc.
Robic
LandOfFree
Functionalization of t cell derived vesicles and use thereof... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functionalization of t cell derived vesicles and use thereof..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functionalization of t cell derived vesicles and use thereof... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1827061