C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 5/08 (2006.01) A61K 47/36 (2006.01) A61L 24/08 (2006.01) A61L 24/10 (2006.01) C08B 37/08 (2006.01)
Patent
CA 2344215
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
La présente invention concerne un procédé permettant une modification chimique de l'acide hyaluronique, la formation d'acide hyaluronique fonctionnalisé amine ou aldéhyde, et leur réticulation pour la formation d'hydrogels. Les hydrogels d'acide hyaluronique ainsi fonctionnalisés se prêtent à la polymérisation in situ. Ils peuvent en outre servir de colle tissulaire, de séparateur tissulaire, de système d'apport de médicaments, de matrice pour culture cellulaire, et d'échafaudage temporaire pour la régénération tissulaire.
Aeschlimann Daniel Peter
Bulpitt Paul Cecil
Orthogene L.l.c.
Smart & Biggar
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