G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) C12Q 1/68 (2006.01) G01N 33/552 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2482611
Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having specific nucleotide sequences, and to separate a mixture of different nucleic acid molecules. The nanoparticles (10) comprise a core (12), a shell (14) coating core (12), and one or more functional groups (16) derivatized onto shell (14).
La présente invention concerne des nanoparticules revêtues de silice fonctionnalisées avec des molécules biologiquement actives telles que des anticorps et des nucléotides. Lesdites nanoparticules sont utilisées pour marquer des cellules, détecter et isoler des molécules d'acide nucléique ayant des séquences nucléotidiques spécifiques, et pour séparer un mélange de molécules d'acide nucléique différentes.
Drake Timothy James
Dytioco Rovelyn Tapec
Hilliard Lisa Renee
Shouguang Jin
Tan Weihong
Torys Llp
University Of Florida
University Of Florida Research Foundation Incorporated
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