C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/103, 167/41,
C07F 15/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07D 257/02 (2006.01)
Patent
CA 1341349
A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes. The chelant has the formula: (See formula I) In the formula R is a 2-10 C alkylene, R' is H or 1-10 alkylene, X and X' each represent hydrogen or together can form a 2-10 C alkylene bridging group, n is 0 or 1, y is 1 to 3 and L is a linker group which allows for attachment to the antibody or fragment thereof.
569508
Fazio Michael J.
Fordyce William A.
Inbasekaran Muthiah N.
Kruper William J.
Pollock Douglas K.
Smart & Biggar
The Dow Chemical Company
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