A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01)
Patent
CA 2654593
The present invention describes polymer nanoparticles having a cationic surface potential, into which both hydrophobic and hydrophilic pharmaceutically active substances can be enclosed. The hydrophilic and thus water-soluble substances are enclosed through ionic complexation with a charged polymer in the core of the particle by means of coprecipitation. It is possible to use as pharmaceutically active substances for encapsulation both therapeutic and diagnostic agents. The cationic particle surface makes stable electrostatic surface modification possible with partially oppositely charged compounds which may, to improve the passive and active targeting, comprise target-specific ligands.
La présente invention concerne des nanoparticules polymères possédant un potentiel superficiel cationique, dans lesquelles des substances pharmaceutiquement actives hydrophobes comme hydrophiles peuvent être encapsulées. Les substances hydrophiles et donc solubles dans l'eau sont incluses dans le cAEur de la particule par complexation ionique avec un polymère chargé en utilisant un procédé de co-précipitation. Comme substances pharmaceutiquement actives à encapsuler, on peut utiliser aussi bien des agents thérapeutiques que des agents de diagnostic. La surface cationique des particules permet une modification de surface électrostatique stable avec des composés de charge en partie opposée, qui peuvent contenir des ligands spécifiques à une cible afin d'améliorer le ciblage passif et actif.
Fischer Katrin Claudia
General Sascha
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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