Functionally selective alpha2c adrenoreceptor agonists

Details Functionally selective alpha2c adrenoreceptor agonists Functionally selective alpha2c adrenoreceptor agonists

C - Chemistry, Metallurgy

07

D

C07D 233/10 (2006.01) A61K 31/4035 (2006.01) A61P 9/00 (2006.01) A61P 25/22 (2006.01) A61P 29/00 (2006.01) A61P 31/10 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2678036

In its many embodiments, the present invention provides a novel class of biaryl compounds as inhibitors of ÿ2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the ÿ2C adrenergic receptors using such compounds or pharmaceutical compositions.

L'invention concerne, dans ses nombreuses formes de réalisation, une nouvelle classe de composés biaryliques constituant des inhibiteurs des agonistes des récepteurs adrénergiques a2C, des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés ainsi que des méthodes visant à traiter, à prévenir, à inhiber ou à améliorer un ou plusieurs états pathologiques associés aux récepteurs adrénergiques a2C au moyen de ces composés ou compositions pharmaceutiques.

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