Functions and targets of let-7 micro rnas

Details Functions and targets of let-7 micro rnas Functions and targets of let-7 micro rnas

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2671299

The present invention concerns methods and compositions for treating or assessing treatment of diseases related to mis-expression of genes or genetic pathways that can be modulated by let-7. Methods may include evaluating patients for genes or genetic pathways modulated by let-7, and/or using an expression profile to assess the condition of a patient or treating the patient with an appropriate miRNA.

L'invention concerne des procédés et des compositions qui permettent de traiter ou d'évaluer le traitement de maladies liées à un défaut d'expression de gènes ou de voies génétiques pouvant être modulés par let-7. Selon les procédés précités, on peut évaluer chez des patients les gènes ou voies génétiques modulés par let-7 et/ou utiliser un profil d'expression pour évaluer l'état d'un patient ou traiter le patient à l'aide d'un miARN approprié.

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