Fungal cell wall synthesis gene

Details Fungal cell wall synthesis gene Fungal cell wall synthesis gene

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/00 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/5377 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 31/10 (2006.01) C07D 213/16 (2006.01) C07D 213/61 (2006.01) C07D 213/65 (2006.01) C07D 213/69 (2006.01) C07D 213/74 (2006.01) C07D 217/18 (2006.01) C07D 217/20 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 40

Patent

CA 2415569

A reporter system reflecting the transport process of GPI anchor protein to cell wall is constructed and a compound inhibiting this process is found out. Further, a gene imparting tolerance to the above compound is identified and a method of screening a compound inhibiting the activity of the protein encoded by this gene is developed. Thus, it is clarified by the novel compound that antifungal agents depending on a novel mechanism, wherein the transport process of GPI anchor protein to cell wall is inhibited, are available.

L'invention concerne la construction d'un système de rapporteurs reflétant le processus de transport d'une protéine d'ancrage GPI vers la paroi cellulaire et la découverte d'un composé inhibant ce processus. En outre, l'invention porte sur l'identification d'un gène conférant une tolérance au composé susmentionné et la mise au point d'un procédé de criblage d'un composé inhibant l'activité de la protéine codée par ce gène. Ainsi, ce nouveau composé permet d'établir que des agents antifongiques dépendant d'un nouveau mécanisme, où le processus de transport de la protéine d'ancrage GPI vers la paroi cellulaire est inhibée, sont disponibles.

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