Fungal micro-organism having an increased ability to carry...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 1/19 (2006.01) C12N 9/02 (2006.01) C12N 15/80 (2006.01) C12P 7/06 (2006.01) C12P 7/10 (2006.01) C12P 7/18 (2006.01)

Patent

CA 2464298

The present invention relates to fungal microorganism having an increased ability to carry out biotechnological process(es). In particular, the invention relates to improving the regeneration of redox cofactors in biotechnological processes where useful products are produced from biomass containing pentoses. According to the invention, the microorganism is transformed with a DNA sequence encoding an NADP linked glyceraldehyde 3- phosphate dehydrogenase. The invention can be used to provide useful products for mankind from biological materials, including e.g. agricultural and forestry products, municipal waste. Examples of such useful products are ethanol, lactic acid, polyhydroxyalkanoates, amino acids, fats, vitamins, nucleotides and a wide variety of enzymes and pharmaceuticals.

La présente invention concerne un microorganisme fongique plus adapté à la mise en oeuvre de processus biotechnologiques. L'invention concerne en particulier l'amélioration de la régénération des cofacteurs d'oxydoréduction dans des processus biotechnologiques permettant d'obtenir des produits utiles à partir de biomasse contenant des pentoses. Selon l'invention, le microorganisme est transformé à l'aide d'une séquence d'ADN codant pour une glycéraldéhyde 3-phosphate déshydrogénase liée au NADP. L'invention peut être utilisée pour obtenir des produits utiles pour l'humanité à partir de matières biologiques, y compris, par exemple, des produits agricoles et forestiers, ou des déchets urbains. Ces produits utiles sont, par exemple, l'éthanol, l'acide lactique, les polyhydroxyalkanoates, les acides aminés, les graisses, les vitamines, les nucléotides et une grande variété d'enzymes et de composés pharmaceutiques.

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